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KMID : 1143420200130201397
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Public Health Weekly Report
2020 Volume.13 No. 20 p.1397 ~ p.1406
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The clinical significance of Pulmonary Arterial Hypertension platform for deep phenotyping in Korean subjects (PHOENIKS) cohort
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Chung Wook-Jin
Jang Young-woo
Park Su-Jung
Oh Pyung-Chun
Ahn Kyung-Jin
You Mi-Ju
Hyun Gyeong-Lim
Oh Se-Yeon
Byun Kyung-Hee
Kim Seung-Woo
Lee Seung-Hee
Kim Won-Ho
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Abstract
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Pulmonary arterial hypertension (PAH) is a progressive, chronic disease without curative treatment. Large registry data of
these patient populations have been published, although, phenotypic variants within each subtype of PAH have not been
elucidated. As interest towards personalized medicine grows, the need for a PAH cohort with a comprehensive
understanding of patient phenotypes through a multiomics approaches, called deep phenotyping, is on the rise. The PAH
Platform for Deep Phenotyping in Korean Subjects (PHOENIKS) cohort was designed to collect clinical data as well as
biological specimens for deep phenotyping in patients with PAH in Korea. A total of 17 regional tertiary hospitals enrolled up to 100 consecutive PAH patients and their family members to obtain clinical data and biological specimens across Korea. PAH is diagnosed by a right-handed catheter examination. All clinical data was registered and managed using the web-based clinical research management system (iCReaT) of the Korea Center for Disease Control and Prevention (KCDC). Each participating collected whole blood samples from each patient, through which DNA, RNA, serum, plasma, and peripheral blood mononuclear cells were extracted from the buffy coat layer for future multiomics analysis. The PHOENIKS cohort enrolled PAH patients across Korea to determine the prognosis and drug response in different phenotypic variants. The data generated by this cohort is expected to open new doors for personalized medicine among in PAH patients in Korea.
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KEYWORD
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Pulmonary arterial hypertension, Deep phenotyping, Precision medicine, Blood bank, Registrie
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